Nutrient Sensing

Acetyl-CoA Regulation Autophagy mTORC1 Regulation

Review Points to AcCoA‑Driven p300 Acetylation as a Neuronal Route to mTORC1 Overdrive

The authors link a leucine‑derived acetyl‑CoA pathway to autophagy failure and protein aggregation and urge targeting upstream metabolic or inflammatory nodes as possible therapeutic directions.