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William Shatner and Daughter Say They Faced Stage 4 Cancers at the Same Time

Their joint account spotlights how modern immunotherapy and HER2-targeted drugs helped produce remissions for both patients.

Overview

  • The pair disclosed in a People interview published Wednesday that Melanie Shatner Gretsch and her father were treated for separate stage 4 cancers around the same period and that both were declared cancer-free in late 2024.
  • Melanie was diagnosed with HER2‑positive metastatic breast cancer in 2022 and completed about 18 months of treatment that included chemotherapy, HER2-targeted therapy, a double mastectomy and 30 radiation sessions.
  • William Shatner received a stage 4 malignant melanoma diagnosis in June 2023 after a lump on his cheek was found to be a tumor; he had surgery to remove the facial tumor and then underwent two years of immunotherapy for disease that had spread to his lungs and brain.
  • The two say family support and practical help shaped their care, with Shatner providing emotional backing and offering to cover medical bills so Melanie would not worry about costs.
  • They plan to launch a weekly podcast focused on survivorship and health on July 29 and use their story to highlight how advances in immunotherapy and HER2-directed treatments and specialized care can improve outcomes for some patients with stage 4 disease.