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Viking Therapeutics Pushes VK2735 Through Pivotal Trials as Next Enrollment Milestone Nears

Analysts' targets signal sizable upside despite tighter cash and notable short interest.

Overview

  • Viking’s Phase 3 VANQUISH program for subcutaneous VK2735 targets obesity with and without diabetes, with weight loss measured over 78 weeks.
  • Enrollment for VANQUISH-1 finished in Q4 2025, and VANQUISH-2 enrollment is expected to complete this quarter.
  • Pivotal readouts are expected next year, setting efficacy and tolerability as the key hurdles in a crowded GLP-1/GIP market.
  • An oral tablet version of VK2735 showed positive Phase 2 results, with Phase 3 initiation planned for the third quarter of 2026.
  • The company reported $706 million in cash and short-term investments at year-end 2025, as Wall Street cites large potential upside, including a $92.72 average price target and a $99 Overweight view from Morgan Stanley, with the stock also flagged as heavily shorted by hedge fund trackers.