Overview
- Club América won 1-0 at Subaru Park in the Round of 16 opener as Raphael Veiga scored in the 20th minute from a Brian Rodríguez setup.
- Luis Ángel Malagón exited injured late in the first half and was replaced by fellow goalkeeper Rodolfo Cota.
- The Union outshot América 12-7 but failed to convert, with Andrew Rick starting in goal for Philadelphia.
- The series shifts to Estadio de la Ciudad de los Deportes on March 18 with América holding a 1-0 aggregate lead under the away-goal tiebreaker.
- The winner advances to face Nashville SC or Inter Miami in the quarterfinal, and Philadelphia enters the week still winless after three MLS defeats.