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UNAM Scientists Turn Scorpion Venom and Habanero Chili Into Experimental Antibiotics

The work signals fresh leads against hard-to-treat hospital infections.

Overview

  • Researchers at UNAM isolated and synthesized two scorpion‑venom benzoquinones and a habanero‑derived peptide, with validation from Stanford’s Richard Zare and pathologist Rogelio Hernández Pando.
  • The blue benzoquinone killed Mycobacterium tuberculosis in mouse models and later showed activity against Acinetobacter baumannii.
  • The red benzoquinone inhibited Staphylococcus aureus, a frequent cause of severe infections in hospitals.
  • A lab‑made version of the habanero peptide, XisHar J1‑1, stopped Pseudomonas aeruginosa in lab tests, though only against a standard strain rather than patient isolates.
  • The team holds patents in Mexico and South Africa and is developing nanoparticle formulations while seeking partners and funding to advance into preclinical and clinical trials.