Overview
- The microfluidic device replicates key liver functions for initial evaluation of medicines with functionality comparable to platforms used in the United States and Europe.
- Findings and methods appear in Advanced Healthcare Materials in a paper detailing ozone and Sulfo-SANPAH treatment for biomimetic long-term cultures.
- The team solved persistent adhesion and viability problems in PDMS chips, maintaining functional cell cultures for several weeks after iterative testing.
- The project was led by first author Mitzi Pérez Calixto with a multidisciplinary team and received support from SECIHTI, postdoctoral funding, and a Fulbright fellowship.
- Researchers report collaborations to build lung- and kidney-on-chip models and plan a fatty-liver variant, noting regulatory moves that could reduce animal testing later this decade.