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UK Regulator Orders Stronger Addiction Warnings on Benzodiazepines, Gabapentinoids and Z‑Drugs

The move seeks to support safer use by highlighting dependence risks with guidance on tapering.

Overview

  • Packaging and patient leaflets will carry the wording: "May cause addiction, dependence, and withdrawal reactions."
  • Updates apply to widely used medicines, including diazepam, lorazepam, temazepam, pregabalin, gabapentin, zopiclone and zolpidem.
  • Patient information will define dependence versus addiction, offer advice on tapering and stopping safely, and prompt conversations with healthcare professionals.
  • The Commission on Human Medicines backed new resources and warnings against combining these drugs with opioids or alcohol and against sharing prescriptions.
  • Manufacturers will roll out changes over a transition period as the MHRA continues safety monitoring, encourages Yellow Card reports, and cautions patients not to stop treatment without medical advice.