Overview
- Published in Nature Medicine, the COSMOS substudy analyzed 958 older adults (average age about 70) randomized to multivitamin or placebo for two years.
- The multivitamin group showed about four months slower biological aging across five DNA methylation clocks, with statistically significant changes on two mortality-predicting measures.
- Participants who were biologically older than their chronological age at baseline appeared to experience larger effects.
- The trial’s cocoa extract arm showed no measurable impact on any of the five epigenetic clocks.
- Haleon supplied the Centrum Silver and partial funding, Mars provided cocoa extract, and investigators note the modest size, limited generalizability, and the need for follow-up to test clinical outcomes.