Overview
- Episode 5, which debuted Wednesday, April 29 on Prime Video, delivers the long-teased on-screen reunion of Supernatural alums Jensen Ackles, Jared Padalecki, and Misha Collins.
- Padalecki appears as Mister Marathon, an ex–Seven speedster, and Collins plays Malchemical, a supe who weaponizes toxic chemicals, joining Ackles’ returning Soldier Boy.
- The story pushes the hunt for V1 — the original Compound V tied to immunity or immortality — with the search now pointing toward legacy supe Bombsight.
- A-list cameos from Seth Rogen, Will Forte, Kumail Nanjiani, and Christopher Mintz-Plasse anchor a set piece that leans into the show’s graphic, R-rated tone without easing its satire.
- Season 5 is the planned series finale with eight episodes total, and new chapters arrive weekly through May 20, with showrunner Eric Kripke’s arc concluding as Amazon positions a Vought Rising prequel next.