Overview
- Houston controlled possession 41:22 to 18:38 and outgained San Francisco 475 to 223, sustaining scoring drives on six of their first seven series.
- C.J. Stroud threw for a season-high 318 yards with three touchdowns and one interception and was not sacked once.
- Mac Jones went 19-of-32 for 193 yards with two touchdowns and one interception as the 49ers mustered little rushing production, including 8 carries for 25 yards for Christian McCaffrey.
- San Francisco's front took further hits with Jordan Elliott (ankle), Dee Winters (knee) and Sam Okuayinonu (ankle) leaving the game, while rookie Alfred Collins briefly exited before returning.
- Kyle Shanahan called the effort unacceptable and downplayed urgency to trade before the Nov. 4 deadline as the 49ers fell to 5-3 and ceded the NFC West lead.