Overview
- Osaka University and Yokohama City University reported in Science the first in vitro creation of mini testis organoids from mouse embryonic stem cells.
- After transplantation into infertile mice, the organoids generated sperm that fertilized eggs and produced live offspring.
- The teams describe the result as a preclinical proof of concept that could advance research on causes of male infertility.
- One Osaka University researcher suggested potential future uses such as producing male hormones outside the body for therapeutic supplementation.
- This study follows the same researchers’ 2021 report of ovarian organoids from mouse stem cells, extending their organoid-based reproductive research.