Overview
- A paper published in Science on May 28, 2026 reports laboratory and GPS-tracked flight experiments that point to iron-rich liver macrophages as candidates for magnetic sensing in homing pigeons.
- In behavioral tests the team used clodronate to deplete macrophages and found treated pigeons lost orientation on overcast days but navigated normally on sunny days when visual cues were available.
- Microscopy and magnetometry showed iron crystallized as oxide nanoparticles inside liver macrophages with superparamagnetic properties and that many of those cells sit next to liver nerve fibers, suggesting a possible path to the brain.
- Several outside experts and the paper's commentators raised key caveats: the lab magnets used are far stronger than Earth’s field, superparamagnetism at the nanoparticle scale may not produce a usable neural signal, and clodronate acts systemically so effects cannot yet be pinned solely to the liver.
- Authors and commentators call for direct neural tracing, liver-specific manipulations, independent replication and tests in other species to confirm whether this mechanism is general, complements other proposed sensors, or is a provisional explanation.