Overview
- Researchers found higher PFNA and PFOSA levels were tied to accelerated epigenetic aging, with the strongest, statistically significant links in men aged about 50–64.
- The study analyzed NHANES 1999–2000 data from 326 adults, measuring 11 PFAS in blood and estimating biological age using 12 DNA methylation clocks.
- PFNA and PFOSA were detected in roughly 95% of samples, while other commonly found PFAS showed no consistent association with aging markers in this analysis.
- The authors emphasize observational limits and do not claim causation, and the American Chemistry Council describes the work as exploratory based on a small, older dataset.
- Policy attention is shifting toward non‑legacy PFAS, with France restricting some consumer uses, the EU considering further limits, and experts advising exposure‑reduction steps as new cleanup research, including sunlight‑driven catalysts, advances.