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Study Links Higher Midlife Vitamin D to Lower Tau on Brain Scans

Researchers say the observational link highlights a possible risk factor that now needs testing in trials.

Overview

  • The Neurology Open Access study, published Wednesday, tracked 793 adults with an average age of 39 and found that higher baseline vitamin D was tied to lower tau about 16 years later.
  • Brain scans showed no relationship between midlife vitamin D and amyloid beta, another hallmark of Alzheimer’s disease.
  • At the start, 34% of participants were below 30 ng/mL, the study’s cutoff for low vitamin D, and 5% reported taking supplements.
  • The authors stressed the results show association rather than proof because vitamin D was measured once and other factors could still drive the link.
  • Tau matters because its buildup tracks with nerve cell loss and cognitive decline, which is why a midlife factor that relates to lower tau could guide future prevention research.