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Study Finds Widespread Rodenticide-Resistance Mutations in Urban Mice

Researchers say the discovery could force cities to rely more on prevention and nonchemical tactics to keep rodent control effective.

Overview

  • The Rutgers study published Wednesday found about 70 percent of house-mouse populations sampled in New York, New Jersey, Pennsylvania and Washington, D.C. carried genetic mutations linked to resistance to common anticoagulant rodenticides.
  • Researchers also detected resistance-linked variants in Norway rats but said most of those mutations have not yet been tested to confirm whether they reduce susceptibility to poisons.
  • Field observations and industry reports cited in the study show rats are increasingly trap- and bait-avoidant and that some treatments now take longer to reduce populations than they once did.
  • The research identified new genetic variants and highlighted Vkorc1, a gene known to confer anticoagulant resistance, prompting calls to reduce reliance on blood-thinning poisons and expand sanitation, exclusion, and trapping programs.
  • Follow-up lab and field tests are needed to measure the new variants' effects, and officials warn cities must act to preserve control options, limit harm to non-target wildlife, and guard public health from rodent-borne diseases.