Overview
- The 1:1 CBD:THC mix produced the strongest effect, synergistically inducing cancer cell death and sharply reducing growth.
- The combination curtailed ovarian cancer cell migration, pointing to potential anti-metastatic activity in early assays.
- Both a platinum-sensitive and a platinum-resistant cell line responded, suggesting applicability across treatment profiles.
- Healthy cells were largely spared in the experiments, indicating selective toxicity compared with many current therapies.
- Mechanistic analyses tied the effects to PI3K/AKT/mTOR inhibition with PTEN activity restored, and the authors call for in vivo and pharmacokinetic studies before clinical testing.