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South Africa Launches National Rollout of Twice‑Yearly HIV Prevention Injection

Health officials say the limited initial supply must be rapidly scaled up to reduce South Africa’s high rate of new HIV infections.

Secunda residents receive medical services at a mobile clinic during the rollout of Lenacapavir in Secunda, South Africa, Friday, June 5, 2026. (AP Photo/Kayleen Morgan)
Young people hold posters as they attend the launch of the Lenacapavir rollout programme in Secunda, South Africa, Friday, June 5, 2026. (AP Photo/Kayleen Morgan)
South African President, Cyril Ramaphosa and Health Minister, Aaron Motsoaledi, among other delegates, hold a box of Lenacapavir during the official launch of the drug's rollout programme in Secunda, South Africa, Friday, June 5, 2026. (AP Photo/Kayleen Morgan)
South African President, Cyril Ramaphosa holds a box of Lenacapavir during the official launch of the drug's rollout programme in Secunda, South Africa, Friday, June 5, 2026. (AP Photo/Kayleen Morgan)

Overview

  • The government has begun distributing lenacapavir, a twice‑yearly injectable form of PrEP that prevents HIV infection and offers an alternative to daily oral pills.
  • A $29 million Global Fund grant paid for doses to cover roughly 456,000 people for one year and the program is being introduced with a focus on people at high risk of HIV.
  • Early distribution is phased by province, with the Western Cape opening the first 22 clinics chosen to serve communities with high HIV burdens.
  • Civil society groups and some public‑health experts warn the current supply is too small to cut national infection rates and call for at least 2 million doses per year; the president has set a target of reaching 3 million people in three years but has not detailed how that will be achieved.
  • Health officials say a voluntary manufacturing license from Gilead could allow local generic production at about $40 per person per year, which would be key to expanding access amid clinic closures and other barriers to reaching key populations.