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Sleep-Like Brain Activity During Wakefulness Tied to Attention Lapses in Adults With ADHD

A mediation analysis indicates that wake slow-wave density statistically accounts for ADHD-related attentional difficulties.

Overview

  • Researchers recorded EEG as 32 medication-withdrawn adults with ADHD and 31 neurotypical adults performed a sustained-attention task, reporting the findings in the Journal of Neuroscience.
  • Adults with ADHD showed a higher density of brief, localized slow-wave activity during wakefulness, a phenomenon described as local sleep.
  • Increased slow-wave density aligned with more omission and commission errors, slower and more variable reaction times, greater mind wandering and mind blanking, and higher sleepiness ratings.
  • Statistical mediation analyses indicated that differences in wake slow-wave density explained the link between ADHD diagnosis and poorer task performance.
  • The team highlights a potential next step to test whether nighttime auditory stimulation that enhances deep-sleep slow waves could reduce next-day local-sleep intrusions as a non-drug option.