Overview
- The Nature Communications paper, published Tuesday, tracked 28 psychedelic‑naive adults who received a 1 mg control session and a 25 mg psilocybin session with EEG, fMRI and DTI.
- During the 25 mg session, EEG, a scalp test of brain activity, showed higher brain entropy within about an hour.
- Participants with more entropy reported greater psychological insight the next day, and those insights tracked with better self‑reported well‑being up to a month, with about 70% saying they felt improved.
- One month later, DTI, an MRI that maps water movement along nerve fibers, found reduced diffusion along tracts linking the prefrontal cortex to deeper regions, with larger shifts in people who had stronger trips.
- Authors and outside experts called the results preliminary, citing the small healthy sample, unclear meaning of the structural shifts, industry ties including drug supply from Compass Pathways, and the need for larger clinical trials with longer follow‑up.