Overview
- Mayo Clinic researchers report that a single 25 mg dose of amphetamine‑dextroamphetamine raised blood pressure, heart rate, and sympathetic activity in Adderall‑naïve young adults.
- The average heart‑rate increase upon standing doubled after dosing, rising from 19 beats per minute to 38 beats per minute.
- The findings come from a randomized clinical trial published March 2, 2026, in Mayo Clinic Proceedings.
- Investigators stress that the results pertain to off‑prescription, single‑dose exposure and should not be applied to supervised ADHD treatment.
- The study responds to rising nonmedical use, noting many users may not realize the drug can acutely strain the cardiovascular system.