Overview
- Analyzing 221 items from 18 questionnaires in 467 adults, researchers derived seven dimensions—anxious, somatic, sensitive, sleep-related, irritable, vigilant and sudomotor—explaining 50.2% of variance.
- Validation in a second cohort of 592 adults confirmed the structure, with the THDQ showing strong fit (CFI 0.92, RMSEA 0.05) and high reliability (Cronbach’s alpha 0.90).
- Most types appeared across insomnia, depression, anxiety, PTSD, panic disorder and ADHD, yet the relative prominence of each dimension differed by diagnosis.
- Multiple regression linked the dimensions to symptom severity across disorders, with standardized beta coefficients ranging from −0.10 to 0.70.
- UK Biobank items can estimate several dimensions (r 0.75–0.85), supporting population-scale research, and labs have begun using the tool with brain-mechanism studies planned.