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Sanofi’s Dual-Target Nanobody Hits Phase 2 Goals in Asthma and Nasal Polyps

The findings point to a new option for patients who do not get relief from current respiratory drugs pending results from larger trials.

Overview

  • Sanofi reported phase 2 wins for lunsekimig in asthma and nasal polyps, a bispecific drug that blocks TSLP and IL‑13.
  • In the AIRCULES phase 2b asthma trial, the drug cut flare‑ups and improved lung function measured by pre‑bronchodilator FEV1.
  • In the DUET phase 2a sinusitis trial, it reduced polyp size and improved nasal congestion and CT scan scores by Week 24.
  • An exploratory atopic dermatitis study missed its main goal yet showed higher skin‑clearance rates on secondary measures.
  • The company described an overall tolerability profile close to placebo and said larger studies and detailed readouts are next.