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2w ago

San Francisco Confirms First Clade I Mpox Case

Officials urge at-risk residents to get both Jynneos doses to blunt spread of the rarer lineage.

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This CDC image shows the characteristic mpox rash on a patient’s skin during the recovery stage. San Francisco has confirmed its first case of clade I mpox in an unvaccinated adult who had contact with an international traveler.
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Overview

  • San Francisco health officials confirmed the city’s first clade I mpox infection in an unvaccinated adult who was hospitalized and is now improving after close contact with a recent international traveler.
  • Authorities say the overall public risk is low and urge people at higher risk to complete the two-dose Jynneos vaccine, which protects against clade I and clade II.
  • California health officials counted the San Francisco patient as the state’s seventh clade I case, following earlier detections in San Mateo County in 2024 and several cases in Los Angeles County.
  • Nationally, the CDC reported 15 clade I mpox cases as of March and said all affected patients were recovering.
  • State data show clade II infections are rising this year in California, averaging 14.5 reported cases per week compared with 3.4 over the same period in 2025, with most recent patients unvaccinated.