Overview
- A peer-reviewed paper published August 5, 2026 reports that Kindred Companion Sciences produced two female beagle pups that lack the Can f 1 protein, the primary allergen for many people.
- Scientists knocked out the Can f 1 gene in canine skin cells with CRISPR and used somatic cell nuclear transfer to create embryos that were carried to term in a surrogate.
- Laboratory assays found no detectable Can f 1 in the pups’ saliva and dander and limited skin‑prick tests, including tests on the lead researcher, showed no immediate allergic reaction.
- The study reports the puppies appear healthy, whole‑genome sequencing found no evidence of off‑target edits, and researchers say they will continue routine veterinary monitoring over time.
- Kindred plans broader testing, breed expansion and regulatory review with the FDA, but experts warn that larger human trials, long‑term animal surveillance, uncertain effectiveness for all allergy sufferers, and ethical impacts on shelters could delay any commercial availability for years.