Overview
- San Francisco improved to 11-4 with a fifth straight win after clinching a playoff berth the previous day.
- Dee Winters capped the night with a 74-yard pick-six on Philip Rivers' last throw.
- Christian McCaffrey rushed for 117 yards and caught two touchdown passes, and George Kittle posted 115 receiving yards with a score.
- Rivers, in his second game back from retirement, went 23-of-35 for 277 yards with two touchdowns and one interception as Indianapolis fell to 8-7.
- The loss extended the Colts' slide and secured AFC playoff spots for the Bills, Jaguars and Chargers.