Overview
- The eNeuro paper reports that DOI switches long-term depression to long-term potentiation in claustrum neurons that project to the anterior cingulate cortex.
- Under psychedelic exposure, activation of these neurons strengthened claustrum–ACC connectivity, an effect not seen under baseline conditions.
- Researchers documented a dense population of serotonin 2 receptors in the claustrum and observed DOI-linked changes in action potential dynamics.
- The team frames the findings as mechanistic support for rapid, lasting circuit plasticity that could help explain the vividness of psychedelic experiences.
- The work uses DOI as a probe in male rats and does not establish behavioral outcomes or clinical efficacy, with translation to humans remaining an open question.