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Princeton Creates 3D Bio-Electronic Neural Device Using Living Cells

The work signals a path for wetware computing that researchers say could ease AI’s energy strain.

Overview

  • Princeton researchers report in Nature Electronics a three-dimensional device that merges living neurons with embedded electronics to carry out computation.
  • The system uses a flexible mesh of microscopic metal wires and electrodes coated in ultra-thin epoxy, and neurons grow through the scaffold for close contact.
  • The embedded array recorded and stimulated activity across multiple layers and stayed stable for more than six months as network connections evolved.
  • After repeated training pulses and algorithmic readout, the biological network learned to distinguish both spatial sources and temporal patterns of electrical signals.
  • The team frames the platform as a step toward ultra–low-power computing and a tool for studying brain development and disease, with real-world uses still requiring major scaling and validation.