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Pfizer Tops Q4 Targets but Posts Loss on $4.4 Billion Write-Downs, Reaffirms 2026 Outlook

Shares slip as the drugmaker prioritizes R&D with debt reduction over buybacks in 2026.

Overview

  • Quarterly revenue reached $17.56 billion versus $16.95 billion expected and adjusted EPS came in at $0.66 versus $0.57, but Pfizer recorded a $1.6 billion net loss after about $4.4 billion in impairments.
  • Covid products continued to decline, with Comirnaty vaccine sales down roughly 35% and Paxlovid down about 75%, partly offset by demand for Eliquis and RSV vaccine Abrysvo.
  • Pfizer reaffirmed 2026 guidance for $59.5–$62.5 billion in revenue and $2.80–$3.00 in adjusted EPS, incorporating pricing pressures and the impact of generic competition.
  • Management outlined around 20 pivotal trial starts in 2026, about half in ultra-long-acting obesity programs acquired with Metsera, with first potential obesity approvals targeted for 2028.
  • The company reiterated that no share repurchases are planned for 2026, is targeting roughly $7.7 billion in cost savings by end-2027, and its stock fell about 3% after the announcement.