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Peru Performs First Mixed ABO-HLA Incompatible Kidney Transplant

Advanced desensitization enabled doctors to overcome dual immunologic barriers, ending the patient's dependence on dialysis.

Overview

  • A 55-year-old husband, Rafael Rivera, donated a kidney to his wife, Edelmira Reyes, in a previously incompatible match.
  • Surgeons at Hospital Nacional Edgardo Rebagliati Martins carried out the procedure on January 21 after a tailored desensitization protocol.
  • The recipient had chronic kidney disease with Fabry disease, a prior graft loss, and a high antibody burden that ruled out deceased or typical family donors.
  • The team removed antibodies against the donor’s blood group A as well as HLA antigens in a first-in-Peru effort led by Dr. Renzo Valdivia and a multidisciplinary unit.
  • EsSalud reports the transplanted kidney is functioning at 100% with dialysis discontinued, and leadership cites the case as evidence of expanded high-complexity transplant capacity.