Overview
- A low-dose combination of zinc, serine, and branched-chain amino acids improved social behaviors in three ASD-linked mouse models.
- The same doses given individually had no effect, indicating a synergistic requirement for the mixture.
- Proteomic analyses showed synaptic protein profiles shifted toward typical patterns, and in vivo imaging found reduced basolateral amygdala hyperactivity.
- Reported by Academia Sinica in PLOS Biology, the regimen modulated circuit activity after one week and improved behavior across Tbr1+/−, Nf1+/−, and Cttnbp2+/M120I mice.
- Researchers and outside experts cautioned against self-supplement use and emphasized the need for safety assessments and human clinical trials.