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Northwestern Performs First U.S. Quadruple-Organ Transplant With Retransplanted Lungs

Machine perfusion extended donor organ viability to allow a staged, less stressful operation that aided the patient’s recovery.

Overview

  • The patient, 36-year-old Elizabeth Wehrle of Iowa, received a second double-lung transplant plus a donor liver and kidney after severe chronic rejection and organ failure from cystic fibrosis.
  • The thoracic team performed the lung retransplant first on the evening of March 22, and abdominal surgeons completed the liver and kidney implants hours later in a sequence that took about eight hours.
  • Surgeons said the case was technically high risk because Wehrle’s 2017 lung transplant left dense chest scarring that distorted anatomy and raised the chance of bleeding and injury during reoperation.
  • Northwestern used machine perfusion to keep donor organs functioning outside the body and buy time for a staged approach instead of attempting a single extremely long surgery.
  • The hospital says this is the first known U.S. quadruple-organ transplant involving retransplanted lungs, one of only a handful of quadruple procedures nationally, and the patient has been discharged, is walking several miles a day, and will return home to her son.