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Newborns Carry Multiple Antibiotic Resistance Genes Within Hours, NICU Study Finds

The pattern suggests maternal transmission with influence from early hospital exposure.

Overview

  • Researchers at ESCMID Global 2026 reported that first-pass stool from 105 NICU infants carried resistance genes within hours of birth.
  • The team screened samples for 56 targets and found near-universal detection of oqxA in 98% of cases and qnrS in 96%.
  • Beta-lactamase genes were common, including blaCTX-M in 55%, blaCMY in 51%, and blaSHV in 39%, and carbapenem-resistance genes appeared in 21% of samples.
  • Each sample contained a median of eight resistance genes, with the msrA gene linked to maternal hospitalization and higher gene counts tied to early central venous catheter use.
  • The authors called for stronger surveillance and infection control in neonatal care and noted the results come from a conference presentation that needs peer-reviewed follow-up to assess clinical impact.