Overview
- City health officials said a single resident tested positive for mpox clade I after recent international travel, marking the first known detection in New York City.
- At-risk New Yorkers are urged to complete the two-dose JYNNEOS vaccine series, and eligible close contacts should seek vaccination within 14 days of exposure.
- Authorities note clade I has been associated with more severe illness than clade II, which drove the 2022 global outbreak, and was linked to deadly outbreaks in the DRC in 2024.
- Transmission occurs primarily through close or intimate contact, face-to-face exposure to respiratory droplets, and direct contact with lesions, with fomite spread considered less common.
- Clinicians are advised that severe cases may warrant treatment with the antiviral TPOXX, though many infections improve with supportive care.