Overview
- Researchers analyzed 283,772 adults aged 50 and older in the NIH All of Us cohort with an average 2.4 years of follow-up.
- Dementia incidence reached 2.6% for people with type 1 diabetes, 1.8% for those with type 2, and 0.6% for participants without diabetes.
- Adjusted risks were 2.82-fold higher for type 1 diabetes and 2.08-fold higher for type 2 compared with no diabetes.
- An estimated 64.5–65% of dementia cases among people with type 1 diabetes were attributed to the condition.
- Outcomes were identified via electronic health records and surveys, prompting calls for longer follow-up, improved phenotyping, and research on subtype-specific mechanisms and prevention.