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NEJM Trial Shows PRIMA Implant Restores Reading Vision for Most Patients With Advanced Macular Degeneration

A wireless subretinal chip paired with camera glasses delivered prosthetic central vision enabling letter recognition, with regulatory filings underway.

Overview

  • In a multicenter European study of 38 people with geographic atrophy, 84% regained the ability to recognize letters, numbers and words, with an average improvement of five lines on a standard vision chart.
  • The system uses a 2mm-by-2mm wireless photovoltaic implant beneath the retina and augmented‑reality glasses that project infrared images processed by a waist‑worn computer.
  • Participants activated the device about a month after surgery and required months of rehabilitation, learning scanning and zoom strategies while using preserved peripheral vision alongside prosthetic central vision.
  • Safety findings included 26 serious adverse events in 19 patients, largely related to surgery, with most resolving within roughly two months and no loss of remaining peripheral vision reported.
  • Science Corporation now leads development, is seeking FDA and CE approvals, and is preparing next‑generation chips with higher resolution and grayscale capabilities following animal testing.