Overview
- Mariano Navone defeated Novak Djokovic in a five-set match, 7-6(5), 5-7, 4-6, 6-2, 6-1, in a 4-hour 36-minute contest that advanced Navone to the US Open second round.
- The upset on Monday ended Djokovic's two-decade run of never losing a Grand Slam opening match and marked his earliest exit at a major since 2006.
- Djokovic showed visible physical problems during the match, including nausea, vomiting, cramps and back and shoulder pain, and he acknowledged those issues in his post-match comments.
- The loss carries immediate ranking consequences because Djokovic was defending 800 US Open points from last year and will drop points that remove him from the ATP top 10.
- Navone, ranked around the 47–49 range, called the victory the biggest of his career and will face the winner of Matteo Berrettini versus Stanislas Wawrinka in round two.