Overview
- A peer-reviewed study in Cell Host & Microbe identifies Rothia and Staphylococcus as bacteria that break down the major peanut allergens Ara h 1 and Ara h 2.
- In allergy-prone mice, introducing the Rothia R3 strain reduced anaphylaxis severity, with smaller body-temperature drops and roughly half the MMCP-1 levels versus controls.
- Among 19 children with peanut allergy, higher salivary Rothia correlated with greater tolerance to peanut exposure during oral immunotherapy assessment.
- Researchers report that an external dataset of 120 children showed Rothia species were more abundant in those with higher reaction thresholds, supporting a potential protective role.
- The teams from the Autonomous University of Madrid and McMaster University propose testing Rothia probiotics, while emphasizing that current human findings are observational and not yet proof of safety or efficacy.