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MIT Bioresorbable Capsule Transmits Proof of Pill Ingestion

Engineers plan to advance from animal results to human trials to address medication nonadherence.

Overview

  • The study, published in Nature Communications, describes a zinc–cellulose radio-frequency antenna paired with a tiny off-the-shelf chip to signal ingestion.
  • In animal testing, the system confirmed swallowing within about 10 minutes and could be detected by an external receiver at distances up to roughly two feet.
  • Most components biodegrade in the stomach within days to a week, while the approximately 400×400 micrometer chip passes through the digestive tract.
  • The antenna is rolled into standard gelatin capsules and temporarily shielded by a cellulose layer with molybdenum or tungsten that blocks RF until the coating dissolves.
  • The team envisions pairing capsules with a wearable receiver for clinician monitoring and is conducting additional preclinical work ahead of planned human testing.