Overview
- Epi‑Phare used France’s SNDS records to compare about 22.7 million vaccinated with 5.9 million unvaccinated adults aged 18–59, with a median 45‑month follow‑up to March 2025.
- Vaccination was associated with a 25% reduction in all‑cause mortality, including a 74% drop in deaths from severe COVID‑19.
- The analysis found no evidence of increased cancer mortality, countering claims of so‑called turbo‑cancers linked to vaccination.
- Serious adverse events such as myocarditis and pericarditis were rare and too infrequent to influence overall mortality, with Moderna previously discouraged for young adults in France.
- Researchers adjusted for detailed sociodemographic and medical factors yet acknowledged potential residual confounding, and the lead author said broad revaccination of all young adults may not be warranted now.