Overview
- Academia Sinica researchers reported that combining zinc, serine, and branched-chain amino acids at low doses benefited three mouse models of autism spectrum disorder.
- The mixture improved social behavior and neuronal communication, whereas the same ingredients given individually at those doses showed no measurable effect.
- Proteomic analyses indicated synaptic protein profiles shifted toward typical patterns, and calcium imaging showed reduced hyperactivity in basolateral amygdala circuits.
- Circuit-level changes emerged after seven days of treatment, alongside improvements in social interaction and, in some tests, associative memory.
- Published in PLOS Biology, the work prompted experts to stress that mouse findings are not clinical guidance and that rigorous human safety and efficacy trials are needed.