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Low-Cost FlightScope Microscope Captures Live Cell Activity in Microgravity Flights

An open design aims to broaden access to microgravity biology beyond ISS-only platforms.

Overview

  • A Newcastle University team adapted a Stanford open-source microscope, ruggedizing it for the harsh dynamics of parabolic flight.
  • During an ESA parabolic flight, the system imaged yeast taking up fluorescent glucose, with uptake appearing slower in microgravity than at 1 g.
  • Rigid mountings, vibration dampers, and a rapid fluid-handling system enabled reliable imaging during repeated ~20-second weightless intervals.
  • The instrument was also tested in the Boulby salt mine analog to study salt-tolerant archaea relevant to astrobiology.
  • The team is sharing the design with researchers and developing a sounding-rocket version for roughly two minutes of microgravity, with results published in npj Microgravity and presented at the Biophysical Society meeting.