Overview
- Participants with neurological Long COVID had roughly 10% larger choroid plexus compared with fully recovered and never-infected groups.
- Advanced MRI showed reduced perfusion within the enlarged choroid plexus among Long COVID cases.
- Greater choroid plexus size correlated with higher blood levels of pTau217 and GFAP, markers linked to Alzheimer’s progression and brain injury.
- Larger choroid plexus volumes were associated with about a 2% lower Mini-Mental State Exam score, indicating modest cognitive differences.
- Researchers describe a possible inflammation-driven vascular remodeling of the choroid plexus, emphasize the cross-sectional design, and plan longitudinal follow-up after publishing in Alzheimer’s & Dementia.