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Lilly, Repertoire Strike Up-to-$1.93 Billion Autoimmune Drug Pact

The collaboration taps Repertoire’s DECODE platform to supply early T-cell–based programs for Lilly under a risk-sharing model.

Overview

  • Repertoire receives $85 million upfront plus up to $1.84 billion in development and commercial milestones, with tiered royalties on sales.
  • The biotech will use its DECODE T-cell receptor–epitope discovery platform to generate up to three autoimmune candidates before handoff to Lilly.
  • Lilly will lead clinical development, manufacturing, regulatory activities, and commercialization of any selected therapies.
  • The partners say they aim for treatments that restore immune balance and deliver durable remission without broad immune suppression.
  • Specific disease targets were not disclosed, as Lilly expands its immunology footprint and Repertoire advances a partnership-focused strategy that includes Genentech, Bristol Myers Squibb, and Pfizer.