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Lilly, Repertoire Strike Up to $1.93 Billion Autoimmune Drug Pact

The pact taps Repertoire’s Decode platform for T‑cell–guided discovery to support Lilly’s expanding immunology portfolio.

Overview

  • Repertoire receives $85 million upfront and is eligible for up to about $1.84 billion in development and commercial milestones plus tiered royalties.
  • Repertoire will use its Decode T‑cell discovery platform to generate up to three autoimmune drug candidates before handing programs to Lilly.
  • Under the agreement, Lilly will lead clinical development, manufacturing, regulatory work and commercialization.
  • The companies have not disclosed which autoimmune diseases they plan to target, and they aim for approaches that avoid broad immune suppression.
  • The deal extends Repertoire’s partnership‑first strategy and comes as Lilly builds out immunology following moves such as the 2024 Morphic acquisition.