Overview
- Researchers at Shanghai Jiao Tong University reanalyzed 326 NHANES samples from 1999–2000 with 12 epigenetic clocks, including the GrimAge measure.
- Higher blood levels of PFNA and PFOSA were associated with markers of accelerated biological aging, with the strongest signals in men aged 50–64.
- PFNA and PFOSA were detectable in roughly 95% of participants, while common compounds such as PFOA and PFOS showed no comparable associations in this dataset.
- The authors emphasize the results show statistical links rather than causation and note potential confounding from lifestyle factors like smoking.
- The study, published in Frontiers in Aging, urges closer scrutiny of newer replacement chemicals and reinforces calls to reduce exposures that remain difficult to avoid.