Overview
- An international team pooled 11 resting‑state fMRI datasets across five countries, totaling 267 people and more than 500 scans, in a Nature Medicine mega‑analysis.
- Psychedelics consistently weakened tight links within brain networks while boosting communication across networks, reshaping how brain systems talk to each other.
- The strongest cross‑talk connected higher‑order association hubs such as the default and frontoparietal systems with vision and movement networks, with added coupling in the thalamus, caudate, putamen, and cerebellum.
- Bayesian modeling quantified uncertainty across drugs, showing the most reliable effects for LSD and psilocybin and wider uncertainty for DMT and ayahuasca due to smaller samples.
- The authors say the map can benchmark future scans and steer treatment design, and they call for larger, more balanced datasets to clarify drug‑specific effects and guide next‑step studies.