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Isaac Guerendo Sidelined by Torn Pectoral, Expected Back Late in Camp

San Francisco must add depth behind Christian McCaffrey to protect his workload.

Overview

  • Coach Kyle Shanahan confirmed Thursday that running back Isaac Guerendo tore a pectoral muscle while lifting weights about a month ago and will miss most of training camp.
  • Shanahan said the injury is not expected to be season-ending and Guerendo could be ready by the end of training camp.
  • The 49ers signed Jordan Mims and Jermar Jefferson and will lean on rookie Kaelon Black and other backups to fill snaps while Guerendo rehabs.
  • Guerendo was a 2024 fourth-round pick who flashed as a rookie but logged no offensive snaps in 2025 and carries a history of hamstring, groin, foot, ankle and shoulder issues.
  • The setback raises durability questions for Guerendo, accelerates competition for the No. 2 running-back job, and forces the team to protect McCaffrey’s workload early in the season.