Overview
- Coach T.J. Otzelberger said X-rays were negative and called it a sprained left ankle, with a reevaluation planned over the next day or two.
- Jefferson left two and a half minutes into the opener after rolling his left ankle and returned to the bench in a boot with crutches.
- Iowa State routed Tennessee State 108–74, setting a program record for points in an NCAA Tournament game.
- Role players powered the win: Killyan Toure posted 25 points and 11 rebounds, Nate Heise scored 22 off the bench, and Blake Buchanan added 11 points with eight assists.
- The Cyclones face No. 7 seed Kentucky in the second round as other contenders such as Duke, Michigan, Houston, Illinois, Nebraska, Arkansas and Texas secured Sweet 16 berths.