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Indoor Tanning Tied to Nearly Triple Melanoma Risk as Study Maps DNA Damage Across the Skin

Researchers paired medical‑record analysis with single‑cell sequencing to show tanning devices drive melanoma‑linked mutations across the skin.

Overview

  • The peer‑reviewed study in Science Advances found a 2.85‑fold higher melanoma risk among indoor tanners after adjusting for age, sex, sunburn history, and family history.
  • Melanoma was diagnosed in 5.1% of tanning bed users versus 2.1% of non‑users in a cohort of roughly 6,000 patients.
  • Single‑cell DNA sequencing of 182 melanocytes from 27 donors showed tanning bed users had nearly twice as many mutations and more pathogenic, melanoma‑linked changes.
  • Users were more likely to develop melanoma on typically sun‑protected sites such as the lower back and buttocks, consistent with widespread mutation patterns across the skin.
  • Study authors and dermatology groups urged stronger warnings and bans for minors, while an industry association questioned confounding in self‑reported data and WHO continues to classify sunbeds as Group 1 carcinogens.