Overview
- The peer-reviewed work, conducted with Monash University’s Prof. Neil Cameron, appears in Biomaterials Science.
- Researchers cultured Jurkat T cells in polycaprolactone electrospun scaffolds, where cells lodged tightly at fibre junctions and resisted manual flushing.
- Accutase outperformed TrypLE and flushing by maintaining higher survival and more normal immune behavior, including post-recovery clustering and growth.
- Scaffold-grown T cells showed stronger in‑vitro cancer cell killing than cells expanded on flat dishes, indicating a dual benefit of the approach.
- The team plans animal studies next and is exploring implantable, T‑cell‑loaded scaffolds to advance adoptive T‑cell therapies such as CAR T.