Overview
- Researchers in Japan report in Cell Metabolism that S‑1‑propenyl‑L‑cysteine, a molecule in aged garlic extract, improved age‑related muscle function in mice.
- S1PC activated the enzyme LKB1 and the SIRT1 pathway in fat tissue, prompting release of eNAMPT in extracellular vesicles that reached the hypothalamus and strengthened nerve signals that aid muscle work.
- In long treatments of old mice, the compound lowered frailty scores, increased skeletal muscle force, and restored core body temperature toward normal.
- A small human readout showed higher circulating eNAMPT after S1PC, with larger changes in people who had sufficient body fat.
- The IRPA–Wakunaga team presents S1PC as a nutraceutical candidate, yet dosing, efficacy, and long‑term safety in people still require controlled clinical trials.